New Insights into CDK Regulators: Novel Opportunities for Cancer ...
WEBCDK/cyclin activity is regulated by CDK inhibitors (CKIs), currently comprising the CDK-interacting protein/kinase inhibitory protein (CIP/KIP) family and the inhibitor of kinase (INK) family. Recent studies have identified a third group of CKIs, called ribosomal protein-inhibiting CDKs (RPICs).
New Insights into CDK Regulators: Novel Opportunities for Cancer ...
WEBMar 3, 2021 · The new cell cycle regulators constitute valuable targets for precision medicine, through the identification of peptides or small molecules mimicking their CDK inhibitor activities, opening novel avenues for the treatment of …
CDK4: a master regulator of the cell cycle and its role in cancer
WEBAug 25, 2022 · The cell cycle is regulated in part by cyclins and their associated serine/threonine cyclin-dependent kinases, or CDKs. CDK4, in conjunction with the D-type cyclins, mediates progression through the G 1 phase …
CDK inhibitors in cancer therapy, an overview of recent …
WEBMay 15, 2021 · To date, the CDK inhibitors (CDKIs), specifically the ones that block the enzyme activity of CDK4 and CDK6 (CDK4/6), have been approved by FDA for the treatment of metastatic hormone receptor positive breast cancer.
CDK regulators—Cell cycle progression or apoptosis—Scenarios …
WEBJan 1, 2023 · Cell cycle regulators aid in controlling the cell cycle's timing. The Cyclins, Cyclin-dependent kinases (CDK), and CDK inhibitors (CDKI) are frequently used as examples of cell cycle regulators (Matthews, Bertoli, & de Bruin, 2022).
The Cyclin-dependent kinase 1: more than a cell cycle regulator
WEBOct 28, 2023 · CDK1, the first identified member of the Cdk family, is conserved in all organisms and regulates the transition between the G2 phase and mitosis. The activity of CDK1 is modulated by its binding...
Core control principles of the eukaryotic cell cycle - Nature
WEBJun 8, 2022 · Evolution of opposing regulatory interactions underlies the emergence of eukaryotic cell cycle checkpoints. CDK5–cyclin B1 regulates mitotic fidelity. CDC7-independent G1/S transition...
The Role of Cell Cycle Regulators in Cell Survival—Dual Functions …
WEBNov 12, 2020 · Cyclin dependent kinase 20 (CDK20) and p21 Cip1/Waf1 are widely recognized as key regulators of cell cycle checkpoints controlling cell proliferation/growth and involving in developing multiple cancers.
Mammalian cell-cycle regulation: several Cdks, numerous …
WEBJun 29, 2009 · Cdk1 activity oscillates during cell-cycle progression and is capable of regulating diverse cell-cycle transitions (G 1 /S, S and G 2 /M phases) by associating with different cell-cycle...
WEBThe new cell cycle regulators constitute valuable targets for precision medicine, through the identication of peptides or fi small molecules mimicking their CDK in-hibitor activities, opening novel avenues for the treatment of cancer and aging-related diseases.