Cyclin-dependent kinases: a family portrait | Nature Cell Biology
WEBBased on sequence similarity, the human genome contains 21 genes encoding CDKs and five additional genes encoding a more distant group of proteins known as CDK-like (CDKL) kinases.
Cyclin-dependent kinase - Wikipedia
WEBIn human cells, the CDK family comprises 20 different members that play a crucial role in the regulation of the cell cycle and transcription. These are usually separated into cell-cycle CDKs, which regulate cell-cycle transitions and cell division, and transcriptional CDKs, which mediate gene transcription.
Cyclin-Dependent Kinases (CDK) and Their Role in Diseases …
WEBMar 13, 2021 · There are 20 members of CDK family known to this day regulating the cell cycle, transcription and splicing. The kinases are organized in a pathway to ensure that, during cell division, each cell accurately replicates its DNA, and ensures its segregation equally between the two daughter cells [2].
Cyclin-dependent kinases: a family portrait - PMC - National …
WEBWe propose here the use of ‘CDK’ for all CDK family members (CDK1-20) based on similarities in sequence and function as described below. This nomenclature will facilitate the rational and comparative study of the poorly understood family members and the analysis of their relevance in human disease.
Structural insights into the functional diversity of the CDK–cyclin …
WEBSep 5, 2018 · Members of the cyclin-dependent protein kinase (CDK) family were originally characterized as serine/threonine-specific protein kinases activated by the expression of cyclin partners to drive the eukaryotic cell cycle [1].
Cyclin-dependent kinases | Genome Biology | Full Text
WEBJun 30, 2014 · The conserved protein kinase domain (red) and some additional domains (see key) are indicated for each CDK. Human cells contain two separate genes, Cdk11A and Cdk11B, each of them encoding a long isoform, Cdk11 p110, and a shorter protein, Cdk11 p58, generated by an internal ribosome binding site.
WEBThe current nomenclature for CDK proteins includes 11 classical CDKs (CDK1–11), two newly proposed family members (CDK12 and 13) and additional proteins whose names are based on the presence...
CDK1 structures reveal conserved and unique features of the …
WEBApr 13, 2015 · CDK1 is the only essential cell cycle CDK in human cells and is required for successful completion of M-phase. It is the founding member of the CDK family and is conserved across all eukaryotes.
The roles, molecular interactions, and therapeutic value of CDK16 …
WEBAug 1, 2023 · The human genome can encode twenty-six CDK family members, of which CDK1-CDK20 are the classical CDKs (CDK11 has two subtypes A and B), and there are five additional CDK members known as CDK-like kinases (CDKL) [1]. There have been extensive research results about many members of the CDK family.
Functional characterization of the human Cdk10/Cyclin Q complex
WEBMar 16, 2022 · Introduction. Cyclin-dependent kinases (CDKs) are serine/threonine-specific protein kinases that get activated upon association of a regulatory cyclin subunit. The family of mammalian CDKs comprises 21 different members, which are involved in cell division and transcription [1].