Kalamazoo is a city in and the county seat of Kalamazoo County, Michigan, United States. At the 2020 census, Kalamazoo had a popu…Kalamazoo is a city in and the county seat of Kalamazoo County, Michigan, United States. At the 2020 census, Kalamazoo had a population of 73,598. It is the principal city of the Kalamazoo–Portage metropolitan area in southwestern Michigan, which had a population of 261,670 in 2020.