An Israeli airstrike killed at least 20 people in central Beirut on Saturday, Lebanon's health ministry said, one of the deadliest strikes on the heart of the capital since Israel began its assault against the Iran-backed Hezbollah group in September.

Israel was targeting a senior Hezbollah commander, but failed to kill him, one Israeli official said. Hezbollah officials said none of the group’s leaders were at the attack site.

The strikes at 4 a.m. destroyed an eight-story building in central Beirut and left a crater in the ground. Also on Saturday, a drone strike killed two people and injured three in the southern port city of Tyre, according to the state-run National News Agency.