Battle-weary firefighters in Southern California are preparing for another Santa Ana wind event that will further compound efforts to contain the deadly and historic Palisades Fire – and potentially fuel new wildfires.

Wildfires began breaking out in Southern California Tuesday morning as a life-threatening, widespread windstorm that could be one of the most destructive to hit the region in over a decade roars to life and creates extremely dangerous fire weather conditions.

Red flag warnings are in effect for parts of Los Angeles and Ventura counties, as the National Weather Service warns that powerful winds and low humidity will increase the risk of fire.

Parts of Southern California that were impacted by severe wildfires last month will be again threatened with critical fire danger in the coming days. The National Weather Service has issued a high wind warning and red flag warning from Los Angeles down to the Mexican border from Tuesday through Wednesday morning.

The Santa Ana winds are a notorious wind event in California. It has been fueling the southern California wildfires.

At least two fires sparked in Southern California on Jan. 7 amid a “life-threatening and destructive” windstorm event that’s sweeping through the region.

The gusty winds that helped spread multiple wildfires gradually subsided on Wednesday afternoon, but dry conditions mean less potent winds could still be dangerous. More strong winds are expected later Thursday.

The Palisades, Eaton and Hurst wildfires raging in Southern California will be fueled by peak winds of 100 mph, placing 19 million people at risk. NBC News meteorologist Angie Lassman has the details on Early Today.

High winds that weather officials have called "life-threatening and destructive" are hitting Southern California Tuesday, sparking a major brush fire in Pacific Palisades and prompting thousands of power outages.