With the Indianapolis Colts' full 2025 NFL schedule now out, DraftKings has odds for all 17 games this season. The Colts are currently favored in just four of them. The difficult part when it comes to projecting what the Colts are going to do this season from a win-loss perspective is the unknown at quarterback.

The Indianapolis Colts ‘ 2024 season ended on a confusing note for the franchise. After star quarterback Anthony Richardson went down with back and foot injuries in week 16, backup Joe Flacco was given the nod to start in his place and went 1-1,

The Colts are facing a critical 2025 season for quarterback Anthony Richardson, coach Shane Steichen and general manager Chris Ballard. With so much riding on their collective progress, each game could matter more than they have in years in Indianapolis. Here are way-too-early game-by-game predictions from IndyStar.