The Indianapolis Colts will be at home fairly often during the early portion of their 2025 NFL schedule. The first two games of the Colts' season will be played at Lucas Oil Stadium. Of their first six games, four will be at home, and of the Colts' first eight games in 2025, five will be at home.

Indianapolis opens the 2025 season with back-to-back games at Lucas Oil Stadium, and even though the Colts will travel the seventh-most miles in the NFL by the end of the season,

On paper, the Colts will have the 12th-easiest schedule, according to Sharp Football. This includes facing six different playoff teams from last season, with five of those games coming on the road. The Colts also play only two teams that picked inside the top 10 in this year's NFL draft.