Running back Christian McCaffrey says the San Francisco 49ers are "hungry" to make a playoff push even with the defending NFC ...

One thing does not change, though. The defending NFC champion 49ers are 5-6 and they need to get on a heater - which will be ...

Providing the betting odds and our preview and prediction for the star-studded matchup between the San Francisco 49ers and ...

The San Francisco 49ers have released their final injury report ahead of their Week 13 bout with the Buffalo Bills.

San Francisco 49ers quarterback Brock Purdy is expected to return to the field on Sunday against the Buffalo Bills after ...

Purdy missed the 49ers' Week 12 contest versus the Green Bay Packers last Sunday with a right shoulder injury—a game San ...

In January, a lake-effect storm forced the NFL to push back the Bills' wild-card playoff home game against Pittsburgh by a ...

Brock Purdy speaks with reporters ahead of San Francisco's Week 13 matchup against the Buffalo Bills on Sunday night.49ers QB ...

Up to three feet of snow could batter the Buffalo Bills’ stadium this weekend, where the San Francisco 49ers are scheduled to ...

Buffalo Bills coach Sean McDermott ruled out Dalton Kincaid from playing against San Francisco on Sunday night, while holding ...

San Francisco 49ers vs Buffalo Bills showdown with essential stats, lineup predictions and injury updates you won’t want to ...