Myelin-specific T lymphocytes are considered essential in the pathogenesis of multiple sclerosis. The myelin basic protein peptide (a.a. 83–99) represents one candidate antigen; therefore, it ...

Multiple sclerosis (MS) is a heterogeneous, immune-mediated disorder in which the body attacks its own myelin sheath that protects the nerve fibers of the central nervous system (CNS).

Multiple Sclerosis Discovery Sheds Light On Unravelling Of Nerves' Protective Myelin Sheath Date: September 15, 2004 ... One specific protein, called myelin basic protein, ...

Reindl, M, Linington, C, Brehm, U, et al. Antibodies against the myelin oligodendrocyte glycoprotein and the myelin basic protein in multiple sclerosis and other neurological diseases: a ...

The presence of citrulline in myelin proteins in particular myelin basic protein (MBP) ... Myelin in multiple sclerosis is developmentally immature. J Clin Invest 1994;94:146–154.

Investigators in our division conduct both basic and clinical research in the areas of experimental allergic encephalomyelitis, immunological and structural studies of the idiotypic network in ...

Multiple sclerosis (MS) is a chronic inflammatory disorder that is thought to impact about 2.3 million people around the ...

Damage to myelin sheaths or to the cells from which they are produced leads to serious disorders such as multiple sclerosis. Researchers from Münster, Germany, a team of scientists at Friedrich ...

Other major myelin constituents include myelin basic protein (MBP), proteolipid protein (PLP), ... One of the most well-known demyelinating diseases is multiple sclerosis ...

In certain diseases like multiple sclerosis, ... C1QL1 protein identified as key to myelin replacement. 1mo. ... Our basic research on C1QL1 is nascent, ...

More information: Bauer, Nina M. et al., Myelin Basic Protein synthesis is regulated by small non-coding RNA 715, ... Multiple sclerosis: Damaged myelin not the trigger. Feb 27, 2012.

In MS, the T cells start to see myelin basic protein, a component of the outside, insulating coating that surrounds nerve cells, as an antigen. They attack the nervous system and, as a result, MS ...