Scientists have uncovered how a protein helps build and maintain vital brain connections, providing insights into the ...

Mouse model confirms early energy loss precedes brain cell death . A groundbreaking study published in Proceedings of the ...

Lafaille, J.J., Nagashima, K., Katsuki, M. and Tonegawa, S. (1994) High Incidence of Spontaneous Autoimmune Encephalomyelitis in Immunodeficient Anti-Myelin Basic Protein T Cell Receptor Transgenic ...

Wucherpfennig, K.W. and Strominger, J.L. (1995) Molecular Mimicry in T Cell-Mediated Autoimmunity Viral Peptides Activate Human T Cell Clones Specific for Myelin Basic Protein. Cell, 80, 695-705.

Our basic research on C1QL1 is nascent, but there is potential that it is relevant for a novel treatment for multiple sclerosis. New drug treatment options for patients with multiple sclerosis ...

In MS, and related animal models, degenerating myelin nudges microglia and macrophages into a phagocytic, inflammatory state so they can clear myelin debris. This state must resolve before ...

The study, “ Myelin Basic Protein in Oligodendrocyte-Derived Extracellular Vesicles as a Diagnostic and Prognostic Biomarker in Multiple Sclerosis: A Pilot Study,” was published in the ...

In contrast to the increased mitochondrial densities in excitatory axons cuprizone-induced demyelination abolished mitochondrial clustering in PV + axons. Furthermore, with genetic deletion of myelin ...

The myelin basic protein (MBP) peptide of amino acids 83–99 (called MBP (83–99) here) is the best examined and is considered one candidate antigen in MS (refs. 1, 18).