Mouse model confirms early energy loss precedes brain cell death . A groundbreaking study published in Proceedings of the ...

Expression of the differentiation inhibitors ID2 and ID4 was enhanced, whereas expression of myelin proteins such as myelin basic protein (MBP) and 2′,3′-cyclic nucleotide phosphodiesterase ...

In this image, an axon appears in green, while abnormal protein clumps (amyloid, red) lodge in tiny channels within the myelin sheath. Amyloid aggregates form filament-like strands across the ...

In patients with MS, damage to the cerebellum often results in the death of these neurons, leading to coordination issues, commonly referred to as ataxia. In their investigation, the researchers ...

Multiple sclerosis (MS) affects more than 2.3 million people around the world. A new study says there's a strong connection between the advanced severity of the disease and the loss of myelin in the ...

Elevated levels of self-reactive antibodies against the Kir4.1 channel, a protein that controls the flow of potassium ions into cells, have been found in the bloodstreams of MS patients.

The limited therapeutic options against the influenza virus (flu) and increasing challenges in drug resistance make the search for next-generation agents imperative. In this context, heterotrimeric ...

Epitope-tagging is an effective tool to facilitate protein enrichment from crude cell extracts. Traditionally, N- or C-terminal fused tags are employed, which, however, can perturb protein function.