Vaughn made the Opening Day roster with the White Sox in 2021 and hit .235 with 15 home runs and 48 RBI. He hit 57 home runs over the next three seasons, including 21 in 2023, when he also drove in 80 runs. He struggled in the early part of 2025 and was sent to the minors before the White Sox traded him to the Brewers.

The Milwaukee Brewers reportedly hope to have veteran first baseman Rhys Hoskins back from a sprained left thumb in the second half of August. However, by the time he returns, it could be too late. Andrew Vaughn may have already hijacked his spot in the lineup by then at this rate, which the team seems at peace with.