San Francisco 49ers running back Isaac Guerendo discussed being the "next man up" with Christian McCaffrey and Jordan Mason expected to miss significant time due to injury.

On Tuesday morning's PFT Live, I threw out the idea of the Bears ditching the normal approach to hiring head coaches and calling the 49ers to see whether they'd be willing to trade Kyle Shanahan.

Running back Christian McCaffrey is on injured reserve for the second time this season, but San Francisco 49ers coach Kyle ...

McCaffrey was initially said to be out at least six weeks — with five weeks left in the season. Niners head coach Kyle ...

ProFootballTalk founder Mike Florio has an intriguing idea for a change of scenery for Kyle Shanahan. Appearing on “The Rich ...

The San Francisco 49ers officially placed Christian McCaffrey on Injured Reserve on Tuesday. McCaffrey's 2024 season is done ...

There are plenty of names on any list of Chicago Bears head coaching candidates, but should the team explore a trade for a ...

Head coach Kyle Shanahan reflected on the team's performance against the Bills, previewed the upcoming Week 14 matchup ...

Isaac Guerendo will make his first NFL start on Sunday as the injury-depleted San Francisco 49ers face the Chicago Bears. The ...

Nick Bosa is one of several San Francisco 49ers players who will not participate in practice on Wednesday as the team begins ...

The San Francisco 49ers are undeniably suffering from the Super Bowl hangover. While it took until the second half of last ...