The San Francisco 49ers running back spot has been a position of focus for fantasy football players throughout the season, ...

San Francisco 49ers rookie running back Isaac Guerendo is dealing with a foot injury and is listed as questionable for Week 15 against the Los Angeles Rams on T ...

Only two games separate the four teams in the NFC West standings. The Seattle Seahawks are on top at 8-6, followed by the Los ...

Deebo Samuel is frustrated with his usage. He should be a focal point if San Francisco 49ers want to make a late playoff push.

Isaac Guerendo was initially uncertain for Thursday night, but the rookie looks like he might give it a go. Here's the latest ...

Everything you need to know about the Rams facing the San Francisco 49ers at Levi's Stadium, including start time, TV channel ...

The 49ers are playing on "Thursday Night Football" against the Rams. Will running back Isaac Guerendo be ready to play after ...

George Kittle is having one of the best seasons of his career. Deebo Samuel is not. On Tuesday in the 49ers locker room, ...

The 49ers got a big win in Week 14 but Deebo Samuel continues to be an afterthought on offense, causing frustration for the wideout.

Head coach Kyle Shanahan and defensive coordinator Nick Sorensen shared injury updates on RB Isaac Guerendo, DL Nick Bosa and more and discussed how the team is preparing for a short turnaround ahead ...

The Los Angeles Rams and San Francisco 49ers are set to square off in a crucial NFC West matchup on Thursday night, live on ...

The San Francisco 49ers didn't anticipate getting down to a fourth-string running back, but they may find themselves in that ...