Plants produce a wide diversity of compounds. Broadly, these are separated into primary metabolites, which are necessary for ...

Prostate cancer (PCa) is the second most frequently occurring cancer and the fifth leading cause of cancer mortality among men worldwide in 2022 (Bray et al, 2024). Androgen receptor (AR) is ...

Arthritis was induced in mice exposed to high blood levels of homocysteine. Hyper-homocysteinemia arthritic animals develop diastolic dysfunction (the left ventricle does not dilate properly) with ...

N6-methyladenosine (m 6 A) exerts many of its regulatory effects on eukaryotic mRNAs by recruiting cytoplasmic YT521-B homology-domain family (YTHDF) proteins. Here, we show that in Arabidopsis ...

Fungal infections and autoimmunity share a complex, bidirectional relationship that significantly impacts patient outcomes. Emerging evidence highlights how fungal pathogens contribute to autoimmune ...

EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

De novo protein design is of fundamental interest to synthetic biology, with a plethora of computational methods of various degrees of generality developed in recent years. Here, we introduce ...

Antibiotic resistance frequently results in delayed adequate antibiotic treatment, increasing morbidity and mortality. AMR is the inherited ability of microorganisms to grow at high antibiotic ...

Plants that germinate in subterranean darkness grow heterotrophically from seed reserves. Under these conditions, hypocotyls elongate rapidly to reach the soil surface and ensure survival, while the ...

The NF-κB activation pathway is based on two fundamental processes. One pathway proceeds by proteolytic degradation of inhibitory IκB proteins, which retain NF-κB DNA-binding subunits in the cytosol.