UroToday3d
Comparison of outcomes between single-port and multi-port robotic radical nephrectomy.
Single-port (SP) robotic surgery is a novel technology, and although there is emerging data, it remains limited in assessing single-port (SP) robot-assisted surgery as an alternative to multi-port (MP ...
UroToday3d
Identification of new tissue markers for the monitoring and standardization of penile cancer according to the degree of differentiation.
Penile cancer is an uncommon disease compared with other urological tumors and is more common in low- and middle-income countries. Risk factors include age, ethnicity, smoking, hygiene, and human ...
UroToday3d
Framework for the Pathology Workup of Metastatic Castration-Resistant Prostate Cancer Biopsies.
Lineage plasticity and histologic transformation from prostate adenocarcinoma to neuroendocrine prostate cancer (NEPC) occurs in up to 15-20% of patients with castration-resistant prostate cancer ...
UroToday3d
Extracapsular extension risk assessment using an artificial intelligence prostate cancer mapping algorithm.
The objective of this study is to compare detection rates of extracapsular extension (ECE) of prostate cancer (PCa) using artificial intelligence (AI)-generated cancer maps versus MRI and conventional ...
UroToday3d
Adverse events after nivolumab and ipilimumab combined immunotherapy in advanced renal cell carcinoma: a multicentre experience in Poland.
Immune checkpoint inhibitors (ICIs) have been employed in the adjuvant and metastatic setting of renal cell carcinoma (RCC) treatment. Among ICIs, combined immunotherapy has the highest risk for ...
UroToday3d
Targeting IRE1α reprograms the tumor microenvironment and enhances anti-tumor immunity in prostate cancer.
Unfolded protein response (UPR) is a central stress response pathway that is hijacked by tumor cells for their survival. Here, we find that IRE1α signaling, one of the canonical UPR arms, is increased ...
UroToday3d
Oncolytic immunotherapy with nivolumab in muscle-invasive bladder cancer: a phase 1b trial.
There is a critical unmet need for safe and efficacious neoadjuvant treatment for cisplatin-ineligible patients with muscle-invasive bladder cancer. Here we launched a phase 1b study using the ...
UroToday3d
Functional inversion of circadian regulator REV-ERBα leads to tumorigenic gene reprogramming.
Profound functional switch of key regulatory factors may play a major role in homeostasis and disease. Dysregulation of circadian rhythm (CR) is strongly implicated in cancer with mechanisms poorly ...
UroToday3d
Active surveillance follow-up for prostate cancer: from guidelines to real-world clinical practice.
To assess active surveillance (AS) adherence for prostate cancer (PCa) in a "real-world" clinical practice. We utilized our institutional database which was built by interrogating electronic medical ...
UroToday4d
Bacillus Calmette-Guérin (BCG) Refractory Non-Muscle-Invasive Bladder Cancer (NMIBC): Current Guidance and Experience from Clinical Practice.
BCG is the standard of care for non-muscle invasive high-risk bladder cancer. Notwithstanding the high rate of cure, cancer may recur. A non-muscle invasive high-risk recurrence may be defined as BCG ...
UroToday4d
Phenotypic evaluation of deep learning models for classifying germline variant pathogenicity.
Deep learning models for predicting variant pathogenicity have not been thoroughly evaluated on real-world clinical phenotypes. Here, we apply state-of-the-art pathogenicity prediction models to ...
UroToday4d
Standard or Extended Lymphadenectomy for Muscle-Invasive Bladder Cancer.
Whether extended lymphadenectomy is associated with improved disease-free and overall survival, as compared with standard lymphadenectomy, among patients with localized muscle-invasive bladder cancer ...