RNA-targeting CRISPR reveals that hundreds of noncoding RNAs …
6 days ago · Not junk, after all. Using CRISPR-Cas13 to edit RNA and avoid off-target activity, the researchers systematically profiled nearly 6,200 gene pairs of long noncoding RNAs (lncRNAs) and nearby ...
Finding Function for Noncoding RNAs Using a New Kind of …
Nov 7, 2024 · Historically, some have even referred to these regions as “junk.”. Now, a new study in Cell finds that some noncoding RNAs are not, in fact, junk—they are functional and play an important role in our cells, including in cancer and human development. Using CRISPR technology that targets RNA instead of DNA, researchers at New York ...
Coding, or non-coding, that is the question | Cell Research - Nature
Jul 25, 2024 · The RNA Atlas expands the catalog of human non-coding RNAs. 17 June 2021. Pan-cancer analysis of transcripts encoding novel open-reading frames (nORFs) and their potential biological functions....
Non-coding RNAs in disease: from mechanisms to therapeutics
Nov 15, 2023 · In this Review, the authors describe our current knowledge of the role of microRNAs, long non-coding RNAs and circular RNAs in disease, with a focus on cardiovascular, neurological,...
Noncoding RNA therapeutics — challenges and potential …
Jun 18, 2021 · Noncoding RNAs (ncRNAs) are generated from the larger part of the genome that does not encode proteins but produces noncoding transcripts that regulate gene expression and protein function. The...
Finding Function for Noncoding RNAs Using a New Kind of CRISPR
3 days ago · Now, a new study in Cell finds that some noncoding RNAs are not, in fact, junk -- they are functional and play an important role in our cells, including in cancer and human development. Using CRISPR technology that targets RNA instead of DNA, researchers at New York University and the New York Genome Center searched across the genome and found nearly 800 noncoding RNAs important for the ...
Abstract 4113573: Long Noncoding RNAs to Predict COVID-19 …
Minimally invasive tools to predict outcome after SARS-CoV-2 infection would enable personalized healthcare, potentially easing the disease burden. We showed that blood levels of the long noncoding RNA lymphoid enhancer-binding factor-1 antisense 1 (LEF1-AS1) predict COVID-19 in-hospital mortality.
Study finds noncoding RNAs dysregulated in several human …
Aug 5, 2024 · Northwestern Medicine scientists have discovered new insights into the production and regulation of a class of noncoding RNAs and how alterations in their signatures diversify and modulate the...
Pumping the brakes on dangerous proteins - Northwestern Now
6 days ago · When a long non-coding RNA called CHASERR (CHD2 adjacent, suppressive regulatory RNA) is deleted, the “foot” is taken off the “brake,” and CHD2 protein production goes into overdrive. While most RNAs make proteins, long non-coding RNAs don't make proteins but are crucial for regulating gene activity.
Finding function for noncoding RNAs using a new kind of CRISPR
2 days ago · Using CRISPR technology that targets RNA instead of DNA, researchers at New York University and the New York Genome Center searched across the genome and found nearly 800 noncoding RNAs important ...